GLUCOSE-6-PHOSPHATE DEHYDROGENASE

IN COMPONENTS OF THE CHICK VERTEBRAL INDUCTION SYSTEM

by Stephen G. Perry Ph.D.

GLUCOSE-6-PHOSPHATE DEHYDROGENASE
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GLUCOSE-6-PHOSPHATE DEHYDROGENASE

IN COMPONENTS OF THE CHICK VERTEBRAL INDUCTION SYSTEM

by Stephen G. Perry Ph.D.

Published Aug 29, 2026
159 Pages
8.5 x 11 Color Paperback
Genre: MEDICAL / Neurology


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Book Details

Within the biological cell, what is embryonic induction?

In 1960 I was at the University of Kansas Medical School Anatomy Department with Chairman Dr. Paul Roofe. The department specialized in NEUROANATOMY. All department members' research interests and teaching expertise were neuroanatomic.

The advisor that was the best fit for me, as I would learn later, was Dr. Byron S Wenger as he was set up with a complete Lowry ultramicrohistochemical Laboratory modified for the procedures to specifically analyze components of embryonic development of the chick nervous system. I submitted a proposal to analyze the spinal cord and its role in the development of the axial vertebrae. It would be a study initially referred to as EMBRYONIC INDUCTION of the VERTEBRA. Dr. Wenger had been in the laboratories of Dr. Victor Hamburger and Oliver H. Lowry so I started with Hamburger-Hamilton Stage 17 assaying glucose-6-phosphate dehydrogenase (G6PDH), the first enzyme in the Pentose Phosphate Metabolic Pathway. Lowry has maintained that “if an enzyme is there, it has a purpose in proportion to its activity." I have reviewed another important function of an enzyme, which is energy transfer from substrate to product, at which time one molecule becomes another with the help of a cofactor. Is EMBRYONIC INDUCTION the unfolding of the genetic code using these energy transfer principles, and shouldn't we be looking here to explain EMBRYONIC INDUCTION?

 

About the Author

Stephen G. Perry Ph.D.

What will graduate school be like? I got off the train in Lawrence, Kansas, walking down Main Street with my footlocker on my shoulder. People were on horseback and in horse-drawn wagons, dressed in frontier garb. I pinched myself and found out it was their Centennial. I found a room to rent. Mount Oread took me up to the campus, where I met with Anatomy Department Chairman Dr. Paul Roofe and got my orientation, and began my graduate career. My first two years were as a medical school teaching assistant with Dr. Irwin Baird (a student of Harvard’s A. S. Roamer) studying the central nervous tracts of pit vipers (rattlesnakes and copperheads). Fine, I’ll get a master's and find a job as a science teacher/football&track coach. Then I met Dr. Wenger and had a chance to study the histochemistry of the developing nervous system and its role in the development of vertebrae.

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